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Once termed “the kings’ disease,” gout used to be a problem primarily for wealthy people and royalty who lounged around drinking wine and eating rich food. But today, an estimated 68% of American adults are either overweight or obese. As a result, gout and type 2 diabetes -- two diseases that can result from an unhealthy lifestyle -- are sharply on the rise.

Gout is an arthritic condition caused by having an excess buildup of uric acid. It causes sudden, extreme attacks of pain, swelling, and redness. Gouty arthritis most often strikes the big toe, but it also can show up in the feet, ankles, knees, hands, and wrists.

Type 2 diabetes, a disease characterized by high levels of sugar in the blood, also can result from eating too much and moving too little.

Gout and type 2 diabetes often co-exist in people with common physical characteristics and conditions, the most prominent being obesity.

“A lot of the risk factors for type 2 diabetes are the same for gout,” says Michele Meltzer, MD, an assistant professor of medicine at Thomas Jefferson Hospital in Philadelphia who specializes in gout. By changing these risk factors, you can help prevent or fight both diseases.

Here’s what you can do:

  • Lose weight. “We are digging our graves with our forks in this country,” says John D. Reveille, MD, director of the division of rheumatology at UT Health Medical School in Houston. To prevent gout, type 2 diabetes, and a host of other health problems, he says you should keep a close eye on your body mass index (BMI) and waist circumference. According to the National Institutes of Health, waist size becomes very important when a person’s body mass index (BMI) is between 25 and 34.9. A BMI over 25 is considered overweight, and a BMI greater than 30 is considered obese. Keep your waist size below 35 inches if you are a woman and 40 inches if you are a man.
  • Exercise regularly. Regular exercise will help control weight and lower high blood pressure, both of which will lower your uric acid level and therefore lessen your chance of developing gout. “Plus, it’s well documented that exercise improves the glucose intolerance associated with type 2 diabetes,” Reveille says. He recommends 30 minutes of moderate activity, at least five days a week. If you're having an acute gout attack or have damaged joints from weight issues, some activities may be difficult. Talk to your health care provider about the best exercise plan for you.
  • Skip the alcohol. A landmark study done by researchers at Massachusetts General Hospital examined the connection between drinking beer and gout. They found that people who drank two to four beers per week were 25% more likely to develop gout. And those who averaged at least two beers a day had a 200% higher risk. “Beer and hard liquor appear to cause a rise in uric acid levels,” Meltzer says. The same doesn't appear to be true with wine, however. Binge drinking is also a very strong risk factor for gout. “Plus, people who eliminate their two beers a day drop weight very quickly, which lowers risk of type 2 diabetes. So you get a two-for-one by cutting out the beer,” she says.
  • Avoid sugar-sweetened beverages. Early research suggests that beverages sweetened with sugar or high-fructose corn syrup, such as regular soft drinks, may increase the chances of developing gout. Even orange juice may increase gout. Eliminating sugary beverages is also a great way to cut calories from your diet, shed a few pounds, and improve your diabetes.
  • Go on a gout diet. A gout diet aims to control uric acid production by reducing intake of foods high in purines. High-purine foods create increased levels of uric acid in the body. Some of the worst high-purine foods are liver and other organ meats, as well as anchovies. Other foods to avoid include lobster, shrimp, scallops, herring, mackerel, beef, pork, and lamb. Don't worry about cutting out purines completely. Just eat these foods in moderation: No more than one serving daily.
  • Eat more dairy.Some studies have shown that drinking skim or low-fat milk or eating low-fat dairy products can help reduce risk of gout, Meltzer says. There is evidence that eating low-fat dairy helps lower risk of type 2 diabetes as well. Aim for 16 to 24 fluid ounces of dairy per day.

 

Do I Have Refractory Chronic Gout (RCG)?

WARNING: ANAPHYLAXIS and INFUSION REACTIONS

See full prescribing information for complete boxed warning.

  • Anaphylaxis and infusion reactions have been reported to occur during and after administration of KRYSTEXXA.
  • KRYSTEXXA should be administered in healthcare settings and by healthcare providers prepared to manage anaphylaxis and infusion reactions.
  • Patients should be pre-medicated with antihistamines and corticosteroids.
  • Patients should be closely monitored for an appropriate period of time for anaphylaxis after administration of KRYSTEXXA.
  • Monitor serum uric acid levels prior to infusions and consider discontinuing treatment if levels increase to above 6 mg/dL, particularly when 2 consecutive levels above 6 mg/dL are observed.
Indications and Usage

KRYSTEXXA® (pegloticase) is a PEGylated uric acid specific enzyme indicated for the treatment of chronic gout in adult patients refractory to conventional therapy.

Important Limitations of Use:
KRYSTEXXA is not recommended for the treatment of asymptomatic hyperuricemia.

Important Safety Information

Before starting KRYSTEXXA® (pegloticase), you should know that:

KRYSTEXXA is for adults who have tried or can not take oral gout medicines and still have high uric acid levels and gout symptoms, also known as refractory chronic gout.

KRYSTEXXA is not recommended if you have high levels of uric acid without symptoms of gout.

You should not receive KRYSTEXXA if you have a genetic condition known as G6PD deficiency, which stands for glucose-6-phosphate dehydrogenase. This is also known as favism. G6PD deficiency occurs more often in people of African or Mediterranean family background. However, it can occur in anyone. Before giving you KRYSTEXXA, your doctor may give you a blood test to determine if you have G6PD deficiency.

Before you receive KRYSTEXXA, tell your doctor if you:
  • Know you have G6PD deficiency
  • Have ever had any heart problems or high blood pressure
  • Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk. You and your doctor should decide if you will receive KRYSTEXXA or breastfeed
What is the most important information I should know about KRYSTEXXA?

Serious allergic reactions may happen in some people who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:
  • Wheezing, shortness of breath, cough, chest tightness, chest pain, or trouble breathing
  • Dizziness, fainting, fast or weak heartbeat or feeling nervous
  • Reddening of the face, itching, hives, or feeling warm
  • Swelling of the throat or tongue, throat tightness, hoarse voice or trouble swallowing
There are possible side effects with KRYSTEXXA:

The most common serious side effects in patients taking KRYSTEXXA were severe allergic reactions and infusion reactions. The most common side effects were gout flares or attacks, infusion reactions, nausea, bruising, sore throat, constipation, chest pain, severe allergic reactions, and vomiting.

An increase in gout flares is frequently observed in patients when they start taking medicines to lower their uric acid levels. Patients do not need to stop taking KRYSTEXXA simply because of gout flares.

Please see enclosed Medication Guide and Prescribing Information, including Boxed Warning.

You are encouraged to report negative side effects of prescription drugs to the FDA by visiting www.fda.gov/safety/medwatch or by calling the FDA at 1-800-FDA-1088.

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