Treatment for ankylosing spondylitis focuses on relieving pain and stiffness, reducing inflammation, keeping the condition from getting worse, and enabling you to continue daily activities. Early diagnosis and treatment may reduce pain, stiffness, inflammation, and deformity.

Talk with your doctor about the best treatment approach for your condition. A consultation with a rheumatologist is often recommended, especially to confirm the diagnosis and lay out a treatment plan. Your family medicine physician or internist can treat mild cases, or you may be referred to a rheumatologist, orthopedist, or physiatrist.

Initial treatment

Initial treatment for ankylosing spondylitis may include:

• Education, so you know what you can expect as ankylosing spondylitis progresses and how you can minimize problems that can be caused by your condition.
• Conditioning and strengthening exercises , to maintain mobility and control pain. People who exercise regularly find they have less pain and stiffness than those who are less active.³
• Nonsteroidal anti-inflammatory drugs (NSAIDs), to relieve pain and stiffness, reduce inflammation, and help with physical therapy. Some people seem to get more benefit from daily NSAIDs than from taking NSAIDs just when they notice symptoms. Talk to your doctor about using NSAIDs for ankylosing spondylitis, including how much to take and how often to take it.
• Physical therapy to maintain proper posture, and deep breathing exercises to enhance lung capacity. A physical therapist can also help you learn to use heat and cold to help control your pain and stiffness. Heat can help with relaxation and pain relief, and cold can help decrease inflammation.
• Assistive devices such as canes or walkers, which allow you to maintain physical activity while reducing stress on joints.
• Alternative therapies such as yoga or acupuncture, which may help relieve pain and improve quality of life.

Have a conversation with your doctor about your job. While people with ankylosing spondylitis feel better if they stay active and exercise regularly, a job that is physically demanding-such as a job that requires lots of heavy lifting-could increase your symptoms.

Ongoing treatment

If initial treatment does not sufficiently reduce the pain and inflammation associated with ankylosing spondylitis, and as your condition progresses, ongoing treatment may include:

• Conditioning and strengthening exercises , to maintain mobility and control pain. People who exercise regularly find they have less pain and stiffness than those who are less active.³ In addition to general conditioning and strengthening, walking and swimming are good activities for people with ankylosing spondylitis. Some people continue to participate in sports as well. Talk to your doctor or physical therapist about activities that will help you and that you will enjoy.
• Medicine. Doctors usually will first recommend nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce pain and inflammation. However, additional, stronger medicines may be needed.
  • Corticosteroids, which are similar to natural hormones produced in the body, help reduce inflammation. Corticosteroids injected into stiff, painful joints may be helpful.¹
  • Disease-modifying antirheumatic drugs (DMARDs) may help relieve pain in joints other than the spine and pelvis. The DMARD most often studied and prescribed for ankylosing spondylitis is sulfasalazine, which is a combination of aspirin and an antibiotic. It is given by mouth (orally) and is available in extended-release tablets. It is also often used to treat rheumatoid arthritis. Some people find that another drug called methotrexate relieves pain in joints other than the spine.
  • Drugs known as "biologic agents" or "anti-TNF-alpha" drugs reduce inflammation by blocking a protein called tumor necrotizing factor (TNF) that causes inflammation.
    • Etanercept is a medicine you inject under the skin.
    • Infliximab is an intravenous medicine that is injected directly into a vein.
    • Adalimumab is a medicine you inject under the skin. It is mostly used for rheumatoid arthritis and psoriatic arthritis, but it is beginning to be used for ankylosing spondylitis as well.
    • Other drugs, especially those used to treat rheumatoid arthritis, are being studied as treatments for ankylosing spondylitis. Talk to your doctor if you are interested in clinical trials of new medicines.
• Physical therapy, to help you maintain good posture, and deep breathing exercises, to enhance your lung capacity. A physical therapist can also help you learn to use heat and cold to help control your pain and stiffness. Heat can help with relaxation and pain relief, and cold can help decrease inflammation.
• Assistive devices such as canes or walkers, which allow you to maintain physical activity while reducing stress on joints.
• Alternative therapies such as yoga or acupuncture, which may help relieve pain and improve quality of life.